The development of high-through-put automated screening has demanded from synthetic chemistry large arrays or libraries of compounds to satisfy the investment made in installing these systems. Will combinatorial chemistry be able to meet this demand? Are the synthesizers well enough developed to meet this? Peptide and oligonucleotide solid phase strategies have been well enough developed over the past 30 years. Will solution methods and other novel chemistries be able to keep apace? Can 'virtual' chemicals be used to remedy 'real' problems? After all, we are living in a real world.
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The primary goal is speed and efficiency. In the past, materials development was driven by slow trial and error. Combinatorial chemistry, often paired with newer technologies like , is helping to streamline this process, overcoming the old trade-offs between accuracy and cost. Peptide and oligonucleotide solid phase strategies have been
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