Juq-158 Jun 2026

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| Endpoint | Findings | Remarks | |----------|----------|---------| | | 120 mg kg⁻¹ | Comparable to many synthetic stimulants; indicates a relatively narrow therapeutic index. | | Cardiovascular effects | Dose‑dependent tachycardia (↑ 30‑70 bpm) and mild hypertension (↑ 10‑20 mmHg) in rats. | Consistent with DAT inhibition. | | Neurobehavioral | At 10 mg kg⁻¹ (i.p.) mice displayed head‑twitch response (a proxy for 5‑HT₂A activation) and increased locomotor activity. | Suggests combined stimulant/psychedelic profile. | | Cytotoxicity (in vitro) | IC₅₀ ≈ 30 µM in HepG2 cells (MTT assay). | Modest cytotoxicity at concentrations far above expected plasma levels. | | Genotoxicity | Negative Ames test (TA98/TA100) and mouse micronucleus assay. | No evident mutagenic risk in standard screens. | | Dependence liability | No published self‑administration or conditioned place‑preference data. | The DAT component raises theoretical abuse potential; formal studies are pending. |

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Juq-158 Jun 2026

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